The cause of acquired immune deficiency syndrome (AIDS), a major human viral disease, is human immunodeficiency virus type 1 (HIV-1), with around 33.2 million people infected worldwide so far. Antiviral agents have been developed which interfere with HIV at various stages of viral replication. The life quality of HIV/AIDS patients has been enhanced by anti-HIV treatment involving chemical drugs. However the key reasons for the failure of anti-HIV therapy are the rise of HIV drug resistance, side effects, and the need for long-term anti-HIV treatment. Therefore in the pharmaceutical industry, the search for new drug candidates with greater inhibitory activity against different HIV strains is growing. Natural bioactive compounds and their derivatives are essential sources of new generation anti-HIV therapeutics that are more effective with less side effects in this respect. Very different types of substances have been obtained from marine organisms because they live in a very challenging, competitive and aggressive environment, a circumstance that involves the development of very complex and potent active molecules, very different in many respects from the terrestrial environment. A number of phloroglucinol-based polyphenols accumulate in marine brown algae as medium, intermediate and high molecular weight phlorotannins containing both phenyl and phenoxy units. A number of interesting SPs, which have been found to exhibit anti-HIV activity with different mechanisms of action, are also known to produce brown algae. Sulfated polymannuroguluronate (SPMG), a new type of sulfated polysaccharide with an average molecular mass of 8.0 kDa isolated from brown algae. Through this review, we can understand about the role of marine derived natural substance in treating and curing of hiv aids. Submit your manuscripts in our journal through given link: https://www.scholarscentral.org/submissions/hiv-aids-research.html