Usually, HIV-positive people recovering from COVID-19 retain viral suppression and do not have major long-term CD4 cell declines, but according to two recent reports, the new coronavirus may trigger more subtle changes that can be detected using specialized tests. Most evidence shows that people living with HIV do not have a higher chance of SARS-CoV-2 coronavirus, nor do they seem to be at a much higher risk of developing or dying from extreme COVID-19. Some HIV-positive persons, however, have had serious illnesses, and some studies have shown higher rates of complications with COVID-19 in this population. Conversely, no work has been performed on the impact of COVID-19 on the progression of HIV disease. Lymphocytes are white blood cells of the immune system, including CD4 and CD8 T cells. Important decreases in CD4 cells were seen in two small retrospective studies, with greater decreases in HIV-negative people with more extreme COVID-19. They noted that COVID-19 also contributes to increased markers of immune activation, inflammation and immune dysregulation, indicating that it is possible that SARS-CoV-2 could have an effect on HIV disease in the short or long term. Our journals main aim is to draws readers' attention to the latest advances in HIV research in the fields of prevention, care and cure. The peoples who are interested to publish their article they can submit their manuscripts in our journal through given link: https://www.scholarscentral.org/submissions/hiv-aids-research.html