Globally, sexual transmission is the dominant mode of HIV spread, with a concomitant epidemic in infants born to HIV-infected mothers. HIV is also spread through contaminated blood, either through sharing of needles and syringes used for illicit intravenous drugs, transfusion of blood and blood products, or contaminated needles and equipment in medical care settings. The differential distribution of HIV worldwide is partly explained by the fact that not all modes of transmission of HIV carry the same risk. Studies have shown that the risk of HIV transmission from male to female is greater than that of transmission from female to male. HIV transmission risks vary by HIV viral load, stage of HIV infection, status of HIV treatment, circumcision status, presence of sexually transmitted infections (STIs), and sexual behavior and sociodemographic factors. HIV is transmitted in utero, during the process of childbirth and through breast-feeding. Most transmission from mother-to-child occurs during childbirth where the mother’s infected blood in the birth canal infects the baby. Breast-feeding, particularly in poor countries, can account for one third to one half of all mother-to-child transmissions. In Asia, it is estimated that there were 8.3 million (5.7–12.5 million) people living with HIV at the end of 2005; 930,000 (620,000–2.4 million) became newly infected with HIV and 600,000 (400,000–850,000) died from AIDS during 2005. Antiretroviral therapy has helped delay the spike of AIDS-related mortality: by the end of 2005, it was reported that 18 countries had achieved the "3 by 5" target of supplying care to at least half of those in need, and the availability of antiretroviral therapy in low- and middle-income countries has risen from at the end of 2003 400,000 to about 1,3 million by the end of 2005. This review tells about the future scope of the new invention towards the field of HIV /AIDS and their medicinal treatment. People who are interested can send their article towards our journal for publication through this link https://www.scholarscentral.org/submissions/hiv-aids-research.html.