AIDS, which first appeared in the early 1980s, is caused by HIV infection. HIV has a genetic payload of RNA, much like the coronavirus responsible for COVID-19. HIV however is a retrovirus and can transforming its RNA into a copy of DNA which it inserts into the genome of the host cell. This viral DNA's longevity makes it possible for HIV to survive in its human hosts for decades. Typically, the virus is transmitted through intercourse with an infected person or through contact with infected blood, needles, or syringes. The virus fuses with white blood cells called helper T cells until it reaches a new host and utilizes their internal machinery to make copies of itself and infect other cells. In order to combat the virus and destroy infected cells, the immune system responds by producing antibodies and creating certain kinds of T cells. Although this reaction can keep the virus under control for a while, often for years, the progressive depletion of helper T cells depletes the capacity of the immune system to combat disease, leaving patients prone to infections and some cancers. Without an effective vaccine, treating enough patients to delay the spread of the virus is the key to reining in the AIDS pandemic. Researchers are now working on formulations of existing AIDS medications that are longer-acting. Twice a day every day, many current medications need to be taken. New formulations of some of these medications can last for weeks or months, including versions that can be injected directly into the muscles. At present, clinical trials are under way. Through this review, we can understand about the aids transmission and development. Submit your manuscripts in our journal through given link: https://www.scholarscentral.org/submissions/hiv-aids-research.html